Haptoglobin deficiency facilitates the development of autoimmune inflammation
نویسندگان
چکیده
منابع مشابه
Haptoglobin deficiency facilitates the development of autoimmune inflammation.
Haptoglobin (HP) is an acute phase protein synthesized by liver cells in response to IL-6. HP has been demonstrated to modulate the immune response and to have anti-inflammatory activities. To analyze HP's effect on autoimmune inflammation, we here studied the course of EAE induced by immunization of Hp knockout (Hp(-/-)) and syngeneic WT mice with myelin oligodendrocyte glycoprotein peptide (M...
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15 صفحه اولHaptoglobin, inflammation and disease.
Haptoglobin is an acute phase protein that scavenges haemoglobin in the event of intravascular or extravascular haemolysis. The protein exists in humans as three main phenotypes, Hp1-1, Hp2-2 and Hp2-1. Accumulated data on the protein's function has established its strong association with diseases that have inflammatory causes. These include parasitic (malaria), infectious (HIV, tuberculosis) a...
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ژورنال
عنوان ژورنال: European Journal of Immunology
سال: 2009
ISSN: 0014-2980
DOI: 10.1002/eji.200939291